Thomas Kremen, MD, began participating in basic science research while obtaining his undergraduate degree in molecular, cellular and developmental biology at the University of California, Santa Barbara. After graduating he continued this work in the field of neuro-oncology at the University of California, Los Angeles in the Laboratory of Linda Liau, M.D., Ph.D. working on translational research aimed at treating malignant brain tumors by activating the body's own dendritic cells. While in orthopedic surgery residency, he continued his research efforts and completed a research fellowship through the California Institute of Regenerative Medicine. As a research fellow, he worked to characterize strategies to better direct the differentiation of mesenchymal stem cells in order to improve the healing of long-bone fractures. Currently, Dr. Kremen and his collaborators in the laboratory of Dan Gazit, PhD, DMD, work to enhance the body's own stem cells to improve healing of bone and joint injuries. Additionally, Dr. Kremen participates in biomechanics research of shoulder and knee reconstruction in collaboration with Melodie Metzger, Ph.D. In March 2015, Dr. Kremen was awarded the Young Investigators Grant from the American Orthopaedic Society for Sports Medicine for his proposal aiming to characterize and optimize the use of stem cells in healing tendon injuries. Also in March 2015, he was awarded a New Investigator Grant from the Orthopaedic Research and Education Foundation in order to improve understanding of the biomechanics of anterior cruciate ligament reconstructions. In August 2017, he was awarded the Western orthopedic Association/Orthropaedic Research and Education Foundation's Young Investigator Award for his work on characterizing the biomechanics of concurrent anterior cruciate ligament and medial collateral ligament injuries in the knee.
Click on the items below for links related to some of Dr. Kremen's research activities:
A cure for osteoarthritis? -read about Dr. Kremen's role in a study funded by the Federal Government's Advanced Research Projects Agency for Health (ARPA-H) dedicating up to $33 million towards finding a game changing treatment of osteoarthritis.
